A recent study carried out by Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University, Alexandria, Egypt compared the outcomes of taking folic acid as opposed to folate, especially in relation to recurring pregnancy loss. In particular in women who had the MTHFR polymorphism.
This polymorphism affects how the methyltetrahydrofolate reductase (MTHFR) enzyme functions. In those with the polymorphism – suspected to impact 20-60% of people – it’s like driving with the brakes on.
This can impair the amount of L-methylfolate available and lead to higher homocysteine levels, which some research is beginning to highlight may be worth noting when trying to conceive. Interestingly, qualified naturopaths have known about the inter-relationship between folate metabolism, homocysteine, fertility, and cardiovascular disease for decades.
Methylation and epigenetics are discussed in more depth in my book.
How does B9 affect pregnancy outcomes?
· Folate is a B vitamin (B9).
· Folate is an important vitamin to take leading up to and throughout pregnancy to reduce the baby’s risk of neural tube defects (like spina bifida) and support healthy DNA replication.
· Folic acid is a synthetic version of the vitamin that you can take as a supplement. And the version of vitamin B9 that has been studied specifically for tube defect prevention.
· Methylfolate is the active metabolite of folate important for DNA repair. It is produced with the help of the MTHFR enzyme (methyl-tetrahydrofolate reductase).
· Some women have an MTHFR gene variation resulting in lower biologically active methylfolate.
· These women may have higher levels of homocysteine, which lead to blood vessel problems and poor circulation between the mother and baby.
Because folate is one of the B-vitamin group, it should always be taken as part of a multi containing all the B-vitamins in the correct dose. Taking just a single B-vitamin can seriously impact others leading to other nutritional deficiencies and imbalances.
For this reason it is essential that you consult a qualified fertility naturopath who is able to assess your needs, identify any genetic polymorphisms, and support your needs with dietary, lifestyle and nutritional supplementation.
Remember, good nutrition is also important for optimal sperm quality.
