Genes, DNA and B-Vitamins
If you are trying to conceive or are pregnant, chances are your doctor will have prescribed folate or mentioned taking a B-vitamin complex. However, not all vitamins are created equal.
Superior Bioavailability and Efficacy of Activated B Vitamins
Activated B vitamins are pre-converted forms that the body can readily utilise without the need for additional processing. This sets them apart from synthetic B vitamins, which require enzymatic conversion. A process that can be inefficient, especially in individuals with chronic health issues or genetic variations affecting nutrient metabolism. For people struggling with conditions like chronic fatigue, cognitive decline, metabolic or reproductive disorders, activated B vitamins provide a superior option to synthetic forms, delivering faster and more effective relief. Clinical studies consistently show that activated B vitamins are absorbed more efficiently and have a more sustained impact on key metabolic processes.
For example, a randomised clinical trial demonstrated that natural B vitamins significantly outperformed synthetic versions in enhancing antioxidant activity and reducing homocysteine levels, a marker associated with cardiovascular risk. These sustained benefits are particularly relevant in managing chronic conditions characterised by oxidative stress and inflammation, both of which significant impact fertility outcomes.
Methylation and MTHFR
Activated B vitamins, particularly B6, B9 (folate), and B12, are integral to maintaining cognitive function and physical energy. These vitamins are key players in neurotransmitter synthesis and mitochondrial health, the latter being critical for cellular energy production.
The active forms of B12 are especially important for individuals with methylation issues or genetic variations that impair the conversion of synthetic B12.
Similarly, active folates like folinic acid and levomefolic acid (5- MTHF) bypass common genetic polymorphisms, such as MTHFR mutations, ensuring efficient energy production and reducing the risk of folate-related deficiencies including neural tube defects in the developing foetus. Clinical studies suggest that daily supplementation with 0.5–1 mg of activated B12 and 400 mcg of 5-MTHF can significantly reduce homocysteine levels and improve cognitive function in at-risk populations. For people with methylation issues, higher doses of folinic acid may be warranted under clinical supervision.
Combining antioxidants and minerals with activated B vitamins, helps neutralise free radicals, reducing cellular damage and supporting sperm and ova quality, thereby forming an integral part to fertility outcomes. This is why quality pregnancy multis contain the essential activated Bs as well as minerals, antioxidants and supportive vitamins.
It is best to consult a qualified naturopath or functional medicine practitioner who can assess your needs and recommend quality supplements.
For recommended pre-conception tests, get your copy of How to Have a Healthy Baby today.
